Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit

Recruiting now

Conditions studied: Weaning Failure of Mechanical Ventilation

In brief

The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are: Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation? What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes? Participants will: Be adults receiving mechanical ventilation and scheduled for weaning Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.

Key facts

Study ID

NCT07075926

Run by

Kanuni Sultan Suleyman Training and Research Hospital

People needed

50

Starts

2025-07-31

Expected to finish

2026-07-16

Last updated by the study team

2025-09-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently receiving mechanical ventilation in the ICU
• Planned extubation after meeting standard weaning criteria
• Hemodynamically stable at the time of echocardiographic evaluation
• Written informed consent obtained from the patient or legally authorized representative

You may not qualify if…

• Surgery within the previous 24 hours
• Presence of significant valvular heart disease or known cardiomyopathy
• Inadequate acoustic window for transthoracic echocardiography
• Ongoing use of extracorporeal support (e.g., ECMO)
• Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours
• Re-intubation planned prophylactically regardless of clinical status
• Pregnant patients

Where it is running

• Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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