Observational Study to Describe Health-Related Quality of Life and Measure Disease Burden Among Patients With Long QT Syndrome Types (LQTS) 2 and 3

Recruiting now

Conditions studied: Long QT Syndrome Type 3, Long QT Syndrome 2

In brief

This is a cross-sectional observational study designed to assess the disease burden and quality of life in individuals with LQTS 2 and 3. Each participant will answer each patient-reported outcome questionnaire only once over a 6-month period. The study will enroll up to 200 participants.

Key facts

Study ID: NCT07075445
Run by: Thryv Therapeutics, Inc.
People needed: 200
Starts: 2025-10-27
Expected to finish: 2026-12-01
Last updated by the study team: 2025-11-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

The participant is willing and provides written informed consent to participate in this study.
Male or female participant of at least 18 years of age, English-speaking.
Confirmed genetic diagnosis of LQT2 or 3, demonstrated by one of the following:
Genetic testing report (pathogenic or likely pathogenic (P/LP) mutation) in KCHN2 or SCN5a genes) or,
A signed physician's letter confirming genetic diagnosis of LQTS 2 or 3.
Documented QTc ≥ 480 ms within the last year, demonstrated by one of the following:
12-lead electrocardiogram (ECG), or
A signed physician's letter confirming an ECG demonstrating QTc value ≥ 480 ms.
The participant is able to operate a smartphone and a companion watch. *The number of participants with QTc between 480 and 500 ms will be limited to 50.

You may not qualify if…

Current participation in another clinical trial involving a drug or device.
Participants unwilling to use an iPhone or Apple Watch for the duration of the study.
Known diagnosis of Brugada Syndrome
Participants unwilling to comply with outlined procedures.

Where it is running

East Carolina University — Greenville, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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