Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit
Recruiting now
Conditions studied: Weaning Failure of Mechanical Ventilation
In brief
The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are: Can the TAPSE (Tricuspid Annular Plane Systolic Excursion) value predict successful extubation? Do other right heart parameters (tricuspid S', RV-FAC, right atrial area, pulmonary valve acceleration time) provide additional prognostic value for weaning outcomes? Participants will: Be adult ICU patients planned for weaning from mechanical ventilation. Undergo transthoracic echocardiography within 2 hours after meeting clinical weaning criteria. Have the following echocardiographic parameters measured: TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. Be monitored for 24 hours after extubation to assess weaning success (defined as no need for reintubation, non-invasive ventilation, or high-flow oxygen support).
Key facts
- Study ID
- NCT07073976
- Run by
- Kanuni Sultan Suleyman Training and Research Hospital
- People needed
- 60
- Starts
- 2025-07-31
- Expected to finish
- 2026-07-16
- Last updated by the study team
- 2025-09-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Receiving invasive mechanical ventilation in the ICU
- Planned extubation (weaning) according to standard clinical criteria
- Hemodynamically stable at the time of transthoracic echocardiography (TTE)
- Ability to undergo echocardiographic assessment within 2 hours prior to extubation
- Informed consent obtained from patient or legal representative
You may not qualify if…
- Known severe tricuspid valve disease or congenital heart disease
- Moderate to severe pericardial effusion or cardiac tamponade
- Inadequate acoustic window for transthoracic echocardiography
- Patients requiring urgent or unplanned extubation
- Use of extracorporeal life support (e.g., ECMO) at the time of assessment
- Known pulmonary embolism or acute cor pulmonale
- Pregnancy
Where it is running
- Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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