Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
Starting soon · Not applicable
Conditions studied: People Who Use Opioids/People With Opioid Use Disorder (OUD)
In brief
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two high-priority interventions: sterile injection equipment and daily oral HIV pre-exposure prophylaxis (PrEP). Outpatient clinics represent an opportune venue to implement these interventions. Yet most clinical providers in these settings do not currently provide them, contributing to a wide gap between evidence and routine practice. The Prescribe to Prevent HIV (P2PH) trial is a participatory study designed to co-develop and pilot test a set of implementation strategies to support outpatients clinics in offering sterile injection equipment and PrEP with the goal of reducing the risk of HIV and SIRI among PWID. This study is supported by the HEAL Initiative (https://heal.nih.gov/).
Key facts
- Study ID
- NCT07073924
- Run by
- University of Pittsburgh
- People needed
- 536
- Starts
- 2026-08-01
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-06-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients with history of active injection drug use in the past 1 year from the 4 COEs
You may not qualify if…
- Ages <18
- If history of injection drug use >1 year
- Non-English speaking
- Pending or legal action that could prohibit or interfere with participation (Ie. incarceration)
- Residence or discharge to a treatment facility that bans the possession of drug checking supplies
- Acute, severe psychiatric condition in need of immediate treatment.
- Clinical Partners:
- Pre-implementation interviews (N=12), pre-implementation focus groups (N = 24), post-implementation surveys (N = 80), and post-implementation interviews (N=10)
- Inclusion Criteria:
- Prescribing clinicians (e.g., physicians, advanced practice providers such as nurse practitioners and physician assistants), administrators, medical assistants, and nurses from the 4 COEs
- Exclusion Criteria:
- Individuals not affiliated with the 4 COEs.
- Staff outside the specified roles (i.e., not prescribing clinicians, administrators, medical assistants, or nurses).
- Students, trainees, or individuals not credentialed in the eligible roles.
- Those on extended leave or not actively working during the study period.
Where it is running
- Latterman Family Health Center — Pittsburgh, Pennsylvania, United States
- Center for Psychiatric And Chemical Dependency Services — Pittsburgh, Pennsylvania, United States
- Internal Medicine Recovery Engagement Program — Pittsburgh, Pennsylvania, United States
- UPMC Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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