A Study of AMC6156 in People With Sarcopenia

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Sarcopenia in Elderly, Sarcopenia

In brief

This clinical trial aims to find out whether AMC6156 can improve physical function and is safe in older adults with sarcopenia. Participants will take AMC6156 or a placebo daily for 12 weeks, and their movement, strength, and safety will be regularly monitored through tests and checkups.

Key facts

Study ID

NCT07072195

Run by

Animuscure Inc.

People needed

80

Starts

2025-07-01

Expected to finish

2027-02-15

Last updated by the study team

2026-08-03

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntary participation with written informed consent
• Male ≥ 65 years or postmenopausal female
• Diagnosed with sarcopenia:
• ASM < 7.0 kg/m² (men) or < 5.4 kg/m² (women)
• Plus low handgrip strength or SPPB ≤ 9
• MNA screening score ≥ 8
• Body weight ≥ 35 kg, BMI between 15-30 kg/m²
• Willing and able to follow exercise and nutrition guidance

You may not qualify if…

• Allergy to investigational drug
• History of GI bleeding, ulcers, or severe liver/kidney/heart disease
• QTc ≥ 450 ms with symptoms
• Severe COPD, uncontrolled diabetes or thyroid disease
• Diseases causing cachexia or muscle wasting (e.g., ALS, Parkinson's)
• Vitamin D deficiency (<10 ng/mL), hemoglobin <10 g/dL
• Severe psychiatric disorders or MMSE < 21
• Inability to walk or recent fracture/surgery affecting mobility
• Use of prohibited medications or recent participation in other clinical trials
• Investigator deems the subject unsuitable for the study

Where it is running

• CHA Bundang Medical Center — Seongnam-si, Gyeonggi-do, South Korea (enrolling)
• Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea (enrolling)
• Ajou University Hospital — Suwon, Gyeonggi-do, South Korea (enrolling)
• Seoul National University Hospital — Seoul, Seoul, South Korea (enrolling)

Full record on ClinicalTrials.gov

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