New Methods for Evaluating Preventive Migraine Treatment
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Migraine, Migraine With or Without Aura, Headache Disorders, Chronic Migraine, Headache
In brief
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, balanced placebo design, patients with chronic migraine will receive four treatment conditions in a randomized order.
Key facts
- Study ID
- NCT07071506
- Run by
- University of Aarhus
- People needed
- 60
- Starts
- 2025-06-19
- Expected to finish
- 2028-09-01
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults (18-65 years)
- ≥ 1-year history of migraine with or without aura according to the International Classification of Headache Disorders (ICHD-3) diagnostic criteria
- Known chronic migraine (headache occurring ≥ 15 days per month for > 3 months, which on at least 8 days per month has the features of migraine headache) diagnosed before age 65
- Eligibility for preventive migraine treatment
- Ability to speak and read Danish
You may not qualify if…
- Use of onabotulinumtoxinA as preventive migraine treatment during the 4 months before inclusion
- Use of other preventive migraine treatment except CGRP antagonists (However, participants are allowed to be on two stable preventive medication (antidepressant, calcium channel blockers, beta blockers or antiepileptic)- 2 months prior to inclusion until end of study), devices for migraine prevention such as transcranial magnetic stimulation and use of nerve blocks 3 months prior to inclusion
- Use of opioid or barbiturate medications in the last four weeks before inclusion
- Secondary headache disorders including medication overuse headache
- Severe psychiatric, vascular disease, or known liver disease
- Alcohol abuse or substance abuse
- Current or planned pregnancy and lactation
Where it is running
- Department of Psychology and Behavioral sciences, Aarhus BSS, Aarhus University — Aarhus C, Denmark, Denmark (enrolling)
- Department of Neurology, Aarhus University Hospital — Aarhus N, Denmark, Denmark (enrolling)
Full record on ClinicalTrials.gov
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