Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
Recruiting now · Not applicable
Conditions studied: Breast Adenocarcinoma
In brief
Breast cancer is the most common cancer worldwide, with over 2.2 million new cases diagnosed in 2020. Treatments such as chemotherapy often lead to a reduced exercise capacity, mainly due to cardiovascular and neuromuscular dysfunctions. This decline appears to be primarily caused by increased central fatigue, while peripheral fatigue remains unchanged. This imbalance suggests a hyperactivation of type III-IV afferent nerve fibers, which are involved in the metaboreflex-a mechanism that significantly influences cardiovascular responses during exercise. Two non-invasive methods, post-exercise circulatory occlusion (PECO) and passive leg movement (PLM), will be used to assess this hyperactivity in patients. Additionally, baroreflex function-crucial for regulating blood pressure-will be evaluated using a direct method to determine its sensitivity and reactivity. By comparing patients with healthy controls under submaximal stimuli, this study aims to better understand chemotherapy-induced cardiovascular dysfunctions. Ultimately, the goal is to design personalized exercise programs to restore cardiovascular function and reduce treatment-related side effects.
Key facts
- Study ID
- NCT07069790
- Run by
- Centre Paul Strauss
- People needed
- 24
- Starts
- 2025-10-02
- Expected to finish
- 2026-10-02
- Last updated by the study team
- 2025-12-31
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Patient group :
- Stage I to III breast cancer
- Having completed (neo)adjuvant chemotherapy treatment less than three weeks ago
- Control group :
- healthy women (no history of cancer) of similar age, weight, and physical activity level
You may not qualify if…
- History of cancer
- Any known chronic pathology
- Protected minor or adult
- Psychiatric, musculoskeletal or neurological problems
- Implantation of a pacemaker
- Pregnant woman
- Presenting at least one contraindication to the use of transient blood flow occlusion
Where it is running
- Institut de cancérologie Strasbourg Europe — Strasbourg, France (enrolling)
Full record on ClinicalTrials.gov
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