Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Recruiting now · Not applicable

Conditions studied: CBD, Cannabidiol, Stress, Acute Stress Reaction

In brief

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Key facts

Study ID

NCT07069478

Run by

University of Minnesota

People needed

125

Starts

2025-06-16

Expected to finish

2028-12-31

Last updated by the study team

2026-07-22

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults who are relatively healthy and aged 21-70 years.
• Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
• Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

You may not qualify if…

• Participated in previous acute stress studies that included a similar stress induction.
• Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
• Self-reported current pregnancy.
• Self-reported current use of illicit substances (other than cannabis).
• Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
• Students of the principal researcher

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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