Prostate Cancer Vaccines

Recruiting now · Phase 1/Phase 2

Conditions studied: Prostate Cancer Indications

In brief

Tumor antigens are protein fragments produced by cancer cells carrying genetic mutations, and many tumor antigens are similar to normal protein antigens, making them unrecognizable by the immune system. Many tumor vaccines are prepared based on a single tumor antigen. This study is based on multiple target antigens using tumor lysates or synthetic peptides. The immune modulation by dendritic-cell (DC)-based cancer vaccines consists of genetically modified DCs to activate T cells to target cancer cells. The study is based on an advanced cancer vaccine technology, which aims to evaluate the safety and potential benefit of the novel immunomodulatory prostate cancer DC vaccines.

Key facts

Study ID

NCT07068555

Run by

Shenzhen Geno-Immune Medical Institute

People needed

30

Starts

2025-06-15

Expected to finish

2028-12-15

Last updated by the study team

2025-07-20

Who can join

Age: 18 and older, up to 80. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed adenocarcinoma of the prostate
• ECOG performance status 0-1
• Life expectancy ≥ 12 weeks
• WBC ≥ 3,500/µL
• Platelet count ≥ 100,000/µL
• Hemoglobin ≥ 10.0 g/dL
• Creatinine ≤ 2.0 mg/dL
• Alkaline phosphatase ≤ 2.5 times upper limit of normal (ULN)
• AST ≤ 2.5 times ULN
• Fertile patients must use effective contraception
• Willing to provide blood samples for research purposes
• Able to complete questionnaire(s) alone or with assistance
• Able to undergo leukapheresis
• No known immunodeficiency
• No other malignancy within the past 5 years except for basal cell or squamous cell carcinoma of the skin treated with local resection only
• No concurrent serious illness
• No known history of positive PPD skin test
• Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) test negative.

You may not qualify if…

• The patient was still using dexamethasone at a dose greater than 4 mg/day during mononuclear cell collection
• Patients have a history of autoimmune diseases or other diseases requiring long-term use of hormones or immunosuppressive drugs
• Patients with a history of allergies or allergies to immune cells and adjuvants of cellular products
• Active infection with fever
• Patients with neutropenia (> 10 days) that are difficult to correct after treatment
• Infection with bacteria, fungi or viruses, uncontrolled
• Patients with HIV and those living with active HBV and HCV
• Severe organ failure (heart, liver, kidney, lung)
• Patients who had previously been treated with cell therapy products and examined by team experts deemed not suitable for treatment
• Anything that researchers believe may increase the risk of subjects or interfere with test results

Where it is running

• Shenzhen Geno-immune Medical Institute — Shenzhen, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.