Weaning Approaches for Vasopressin in Sepsis

Recruiting now · Phase 3

Conditions studied: Septic Shock

In brief

In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.

Key facts

Study ID

NCT07067866

Run by

Hospital Nossa Senhora da Conceicao

People needed

82

Starts

2025-10-01

Expected to finish

2028-10-01

Last updated by the study team

2026-01-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age over 18 years
• Admitted to the Intensive Care Unit
• Patients with vasopressor dependent sepsis
• Receiving combined norepinephrine and vasopressin therapy

You may not qualify if…

• Withdrawal/reduction of vasopressin related to a plan of treatment limitation or palliative care
• Withdrawal/reduction of vasopressin associated with the initiation of adrenaline or any other vasopressor

Where it is running

• Hospital Nossa Senhora da Conceição — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)

Full record on ClinicalTrials.gov

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