Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations

Starting soon · Not applicable

Conditions studied: Respiratory Failure, Extubation Failure

In brief

subjects on mechanical ventilator who are about to be extubated to Non invasive ventilation because the physician thinks they are high risk for failure will be approached and consented for our study. Once randomized they will either be on the standard of care Non invasive arm or the intervention arm which would mean they are placed on the Biphasic cuirass ventilation.

Key facts

Study ID

NCT07067502

Run by

University of Missouri-Columbia

People needed

50

Starts

2026-10-01

Expected to finish

2027-07-30

Last updated by the study team

2026-07-28

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• High risk extubation patients in the Medical Intensive care units who are being thought to be placed on non invasive ventilator post extubation.

You may not qualify if…

• Age <18 or >80
• Pregnant
• Inmate/Prisoner
• Chest wall defects
• BMI >50
• History of Diaphragmatic paralysis
• History of Neuromuscular disease
• Contraindication to study device (open chest wound, flail chest, complex thoracic surgeries in the past)

Full record on ClinicalTrials.gov

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