Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease

Recruiting now · Not applicable · Has a placebo group

Conditions studied: ALS (Amyotrophic Lateral Sclerosis)

In brief

Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.

Key facts

Study ID

NCT07067229

Run by

Chulalongkorn University

People needed

100

Starts

2025-08-01

Expected to finish

2027-12-30

Last updated by the study team

2025-09-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants aged between 18 and 80 years
• Diagnosed with any type of motor neuron disease (MND)
• Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3

You may not qualify if…

• History of other neurological disorders, such as stroke
• Use of ventilatory support
• Severe dementia

Where it is running

• King Chulalongkorn Memorial hospital, The Thai Red Cross Society — Bangkok, Pathumwan, Thailand (enrolling)

Full record on ClinicalTrials.gov

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