The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
Recruiting now · Not applicable
Conditions studied: Respiratory Disease (Clinically Stable Individuals - Patients Recovered From Respiratory Disease)
In brief
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing. Participants will : 1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed. 2. baseline characteristics will me monitored throughout the interventions 3. Esophageal pressure and minute ventilation will be monitored.
Key facts
- Study ID
- NCT07066566
- Run by
- Larissa University Hospital
- People needed
- 30
- Starts
- 2024-04-09
- Expected to finish
- 2025-09-01
- Last updated by the study team
- 2025-07-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age ≥18 years old
- absence of symptoms and signs of respiratory failure (SpO2>95% at FiΟ2 0.21)
You may not qualify if…
- pregnancy
- SpO2<94% at FiΟ2 0.21
- neuromuscular disease
- contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, esophageal disease, nasal trauma, allergy to local lidocaine)
Where it is running
- University Hospital of Larissa, Department of Pulmonary Medicine — Larissa, Greece (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.