Ketone Esters for Optimization of Operator Performance in Hypoxia

Completed · Not applicable · Has a placebo group

Conditions studied: Hypoxia

In brief

The primary purpose of the study was to investigate effects of an orally administered ketone ester drink on endurance exercise performance during acute extreme hypoxia. Drinking this ketone supplement increases energy substrates known as ketone bodies in the blood, which may also act as metabolic signaling molecules. The ketone drink used in this study is recognized by the FDA as generally regarded as safe (GRAS). Some reports suggest that high ketone levels may enhance one's ability to tolerate hypoxia.

Key facts

Study ID

NCT07065864

Run by

Florida Institute for Human and Machine Cognition

People needed

17

Starts

2023-08-04

Expected to finish

2023-11-14

Last updated by the study team

2025-07-15

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult males 18 years of age or older (females are excluded because the 7th SFG consists only of males)
• Able to provide informed consent
• Able to perform the prescribed exercise and all study assessments
• Proficiency with the English language (reading, writing, speaking)

You may not qualify if…

• Any health or medical condition (e.g., cardiovascular, respiratory, musculoskeletal, neurologic) that would preclude exercise testing or potentially influence exercise performance, as determined by health and medical history questionnaire.
• Any condition that would preclude an accurate DXA body composition scan (e.g. joint replacement).

Where it is running

• Florida Institute for Human and Machine Cognition — Pensacola, Florida, United States

Full record on ClinicalTrials.gov

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