Cryocompression for CIPN
Recruiting now · Not applicable
Conditions studied: Chemotherapy-induced Peripheral Neuropathy, Taxane-Induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
In brief
This study aims to evaluate the effectiveness, tolerability, and safety of using cooling therapy and pressure (cryocompression) to reduce peripheral neuropathy, a condition affecting the nerves supplying the arms and legs (limbs) resulting in possible numbness, pain, and/or loss of motor function, that may occur as a result of taxane-based chemotherapy. The name of the device used in this research study is: -Paxman Limb Cryocompression System (PLCS)
Key facts
- Study ID
- NCT07064798
- Run by
- Dana-Farber Cancer Institute
- People needed
- 50
- Starts
- 2025-10-22
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults > 18 years of age
- Gynecologic or breast malignancy
- Starting 1st cycle of treatment with chemotherapy regimens:
- Weekly paclitaxel x 12 or weekly paclitaxel/carboplatin x 12, Q2 weeks paclitaxel X4 (preceded by doxorubicin/cyclophosphamide). (Breast Oncology)
- Q3 weeks paclitaxel/carboplatin X 6-8 (GYN)
- Receiving treatment on the main campus of DFCI (these patients are currently seen on Yawkey 9 and 10 and at Chestnut Hill)
- Able to complete questionnaires in English or Spanish
You may not qualify if…
- Previous exposure to neurotoxic chemotherapy
- Pre-existing neuropathy
- History of Raynaud's phenomenon, cold agglutinin disease, cryoglobulinemia, cryofibrinogenemia, post-traumatic cold dystrophy, peripheral arterial ischemia, or sickle cell disease
- Undergoing desensitization
- Lymphedema in the limb where the device would be applied
- Open skin wounds or ulcers of the limbs where the device would be applied
Where it is running
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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