Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

Recruiting now · Not applicable · Has a placebo group

Conditions studied: High Altitude Hypoxia, Exercise

In brief

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Key facts

Study ID

NCT07063732

Run by

McMaster University

People needed

14

Starts

2025-05-28

Expected to finish

2025-08-31

Last updated by the study team

2025-07-14

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

You may not qualify if…

• BMI > 30
• No prescribed medications (oral contraceptives excluded)
• History of smoking
• Currently following a ketogenic diet or consuming exogenous ketogenic supplements
• History of heart, lung, blood vessel, or kidney disease
• Currently pregnant

Where it is running

• Barcroft Research Station — Bishop, California, United States (enrolling)
• University of Guelph — Guelph, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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