Assessment of Circuit Rebreathing During CPAP Therapy

Recruiting now · Not applicable

Conditions studied: Obstructive Sleep Apnea (OSA)

In brief

The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).

Key facts

Study ID

NCT07062770

Run by

Brigham and Women's Hospital

People needed

13

Starts

2025-05-27

Expected to finish

2025-12-01

Last updated by the study team

2025-07-14

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Moderate to severe OSA (AHI>20)
• Self-reported CPAP users or have previously used CPAP
• Self-reported holding pressure of maximum 13 cmH2O (if known)
• Age: 21-70
• BMI: 18-40 kg/m2

You may not qualify if…

• Self-reported severe mouth-breathing
• Requirement for nocturnal supplemental oxygen or other ventilatory support
• Severe cardiovascular or pulmonary disease
• Any unstable or acute medical condition
• Any additional sleep disorder, including insomnia, except for OSA.

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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