Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis
Recruiting now
Conditions studied: Meningitis, Bacterial Infections, Viral Meningitis, Fungal Meningitis
In brief
Prospective, multicenter, observational clinical registry of pediatric patients with acute infectious meningitis across approximately 20 public and private hospitals in Brazil. The study will include children under 18 years of age with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols.
Key facts
- Study ID
- NCT07062445
- Run by
- Hospital Israelita Albert Einstein
- People needed
- 600
- Starts
- 2026-03-29
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-05-05
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Fever (axillary temperature ≥37.8°C) followed by two or more of the following symptoms*: severe headache, vomiting, altered consciousness (confusion, drowsiness, or irritability), photophobia (increased sensitivity to light), presence of seizures OR
- Fever accompanied by at least one meningeal irritation sign, such as neck stiffness, Kernig's sign, or Brudzinski's sign OR
- Sudden onset of fever and appearance of petechial skin rash or hemorrhagic suffusions
- In children younger than two years, in addition to the presentations listed above, consider fever with any of the following: irritability, persistent crying, somnolence, or bulging fontanelle.
You may not qualify if…
- Refusal to provide consent for study participation
Where it is running
- Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil (enrolling)
Full record on ClinicalTrials.gov
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