A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

Running, not enrolling · Not applicable

Conditions studied: Infertility, Male Factor Infertility

In brief

This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.

Key facts

Study ID

NCT07062237

Run by

UConn Health

People needed

187

Starts

2025-07-27

Expected to finish

2026-09-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older, up to 42. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age.
• Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination.
• Subjects are utilizing standard insemination or ICSI for fertilization.
• Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders).
• Subjects are willing to comply with study protocol and procedures and provide written informed consent.

You may not qualify if…

• Subjects are utilizing donor oocytes, donor sperm, or gestational carrier.
• Subjects have a diagnosis of cryptozoospermia (no spermatozoa identified in fresh semen sample).
• Subjects are utilizing surgically removed sperm (e.g. via testicular sperm aspiration [TESA] or microsurgical epididymal sperm aspiration [MESA]).
• Subjects are utilizing frozen/thawed sperm, including in cases in which a fresh sample was planned and the sample is insufficient for use.
• Subjects are utilizing frozen/thawed oocytes.
• Subjects undergoing PGT-SR (PGT for structural rearrangements).
• Subjects are undergoing a day 3 (cleavage stage) embryo transfer.
• Subjects obtain less than 6 mature oocytes at the time of oocyte retrieval for ICSI or less than 8 oocytes at the time of oocyte retrieval for standard insemination.
• Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination but choose to fertilize fewer than 6 (for ICSI) or 8 (for standard insemination).
• Male partner is unable to produce a second semen sample within three hours of the first semen sample (standard abstinence sample)
• Male partner has an infectious disease.

Where it is running

• The Center for Advanced Reproductive Services, P.C. — Farmington, Connecticut, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.