Acoustics as a Metric of Airway Pressure in Premature Infants Using Bubble Continuous Positive Airway Pressure
Recruiting now
Conditions studied: Preterm Infant
In brief
This is an observational, proof-of-concept, feasibility study where 30 preterm infants on bubble CPAP with gestational age \< 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's Hospital. The study's main goals are: 1. To determine the relationship between ambient bubbling sounds and delivered pressures in preterm infants on bCPAP. 2. To determine the relationship between transmitted bubbling sounds and airway pressures transmitted to the lungs of preterm infants on bCPAP. 3. To develop models to predict delivered and transmitted bCPAP pressures from the acoustic properties of bubbling sounds.
Key facts
- Study ID
- NCT07060833
- Run by
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- People needed
- 30
- Starts
- 2025-04-03
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-03-30
Who can join
Age: 1 and older, up to 1. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Infants on bCPAP with gestational age < 32+0 weeks
- Postmenstrual age between 28+0 and 36+6 weeks at the time of the study
- Postnatal age greater than 168 hours (7 days) at the time of the study
- On the bubble CPAP device with binasal prongs at the time of the study
- Receiving bubble CPAP levels of 5 to 7 cm H2O with gas flows between 6L/min and 10L/min at the time of the study
You may not qualify if…
- Infants with known major congenital anomalies
- Infants with known congenital heart disorders
- Infants with known neuromuscular disease
- Infants receiving ventilator-derived CPAP at the time of the study
- Infants receiving CPAP via a nasal mask interface at the time of the study
- Infants receiving inotropes, narcotics or sedative agents at the time of the study
- Infants deemed clinically unstable for the study by the attending neonatologist
Where it is running
- McGill University Health Center — Montreal, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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