Vascular Effects of SGLT2i in Non-diabetic CKD
Starting soon · Phase 2 · Has a placebo group
Conditions studied: Non-diabetic Chronic Kidney Disease
In brief
Empagliflozin, a sodium-glucose co-transporter 2 inhibitor (SGLT2i), is a novel diabetic medication that reduces the risk of progression of chronic kidney disease (CKD) and heart failure and improves exercise tolerance regardless of the diabetes status. One of the important ways that empagliflozin improves health may be through its benefits on blood vessels. The effects of empagliflozin on blood vessels and physical function have not been examined in patients with chronic kidney disease, and it is less clear if empagliflozin may be beneficial in patients with chronic kidney disease without heavy urinary protein leakage. The investigators will examine if empagliflozin can improve blood vessel function and exercise tolerance in Veterans with chronic kidney disease without heavy urinary protein leakage.
Key facts
- Study ID
- NCT07060417
- Run by
- VA Office of Research and Development
- People needed
- 52
- Starts
- 2026-08-01
- Expected to finish
- 2029-09-30
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adults aged 18 years of age or older
- eGFR 20-59 mL/min
- albuminuria <300 mg/g
You may not qualify if…
- Type 1 or 2 diabetes mellitus
- expected to start dialysis or receive kidney transplantation or die within 4 months
- prior therapy with SGLT2i within the previous year
- unable to participate in the physical function tests (hand grip, walk)
- infections requiring intravenous antibiotic treatment
- malignancy requiring systemic therapy
- extremity skin ulceration requiring active therapy
- history of Fournier's gangrene
- severe hypoglycemia requiring external assistance within the past one year
- known allergy to empagliflozin
- pregnancy
Where it is running
- VA Salt Lake City Health Care System, Salt Lake City, UT — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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