Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma

Recruiting now · Not applicable

Conditions studied: Human Papilloma Virus Related Carcinoma, Tonsillar Squamous Cell Carcinoma

In brief

This prospective research study aims to see if pre-operative MRI can predict the margin status after transoral robotic surgery (TORS) for human papillomavirus positive (HPV+) tonsillar squamous cell carcinoma (SCC). The pre-operative MRI will have a standard MR neck without and with contrast, with added axial T2 weighted sequence and T2 SPACE sequence through the tonsils. Three neuroradiologists will grade the thickness of the pharyngeal constrictor muscle (the muscle that surrounds the tonsils) on a five-point scale. The study will determine if the pre-operative MRI grading will correlate with positive, insecure (\<1mm), or secure (\>1mm) margin during TORS surgery for your HPV+ tonsillar SCC.

Key facts

Study ID

NCT07060261

Run by

Case Comprehensive Cancer Center

People needed

30

Starts

2025-11-26

Expected to finish

2026-09-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥ 18 years of age.
• Participants being considered for TORS for HPV+ tonsillar SCC.

You may not qualify if…

• Participants < 18 years of age.
• Participants who cannot provide informed consent.
• Participants who do not wish to participate.
• Vulnerable populations, including but not limited to cognitively impaired persons, pregnant women, and students or house staff under the direct supervision of the investigator.
• Participants in whom MRI is contraindicated.

Where it is running

• Case Comprehensive Cancer Center, Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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