Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation

Withdrawn before enrolling · Not applicable

Conditions studied: Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction Rehabilitation

In brief

This study will investigate whether knee joint manipulation can improve neurocognitive and neuromuscular performance in individuals with a history of anterior cruciate ligament reconstruction (ACLR). Recruitment will consist of 30 participants aged 18-35 who are 4 months to 5 years post-ACLR and demonstrate measurable reaction time delays. Using a within-subject pre-post design, participants will complete a battery of neurocognitive and neuromuscular assessments, including visuomotor reaction time and dual-task hop testing, before and after knee joint manipulation(s). The main questions the investigators aim to address are: Aim 1: Evaluate the feasibility, acceptability, and applicability of integrating knee joint manipulation into post-ACLR rehabilitation using the Implementation and Outcomes Framework. Aim 2: Determine preliminary efficacy of knee joint manipulation on neurocognitive performance in individuals with ACLR.

Key facts

Study ID

NCT07058467

Run by

University of North Carolina, Chapel Hill

People needed

0

Starts

2025-08-01

Expected to finish

2026-04-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provided informed consent prior to any study procedures that are performed.
• Are between the ages of 18 and 35.
• Have undergone ACLR surgery. All autograft and allograft types are accepted.
• Are 4-months to 10-years post-ACLR.
• Injured knee playing or training for sports (recreational or organized) or during physical activity.
• Have been cleared by a physician to return to activities and/or participate in this study.
• Are at least the minimally clinical important difference (MCID) above the normative reaction time average for our methods as established by previous literature in at least 1 reaction time task.

You may not qualify if…

• History of concussion in the past 3 months.
• The participant is pregnant.
• Have a neurological disorder, including epilepsy.
• Currently injured or have injured their lower extremity in the past 3 months.
• Had surgery on multiple ligaments when their ACL was injured.

Where it is running

• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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