The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage

Recruiting now · Not applicable

Conditions studied: Osteomyelitis, Diabetes, Calcanectomy

In brief

The ACHILLS Trial is a multicentre randomised controlled feasibility study comparing partial calcanectomy with and without the use of an antibiotic-impregnated bone graft substitute (Cerament G) for treating calcaneal osteomyelitis, specifically on wound healing rates, re-infection, and overall efficacy in a sample of 30 patients over a one-year period.

Key facts

Study ID

NCT07057817

Run by

Royal College of Surgeons, Ireland

People needed

30

Starts

2026-01-01

Expected to finish

2029-12-01

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 and over
• Undergoing partial calcanectomy
• Patients with Type1 or Type 2 Diabetes
• Patients will be stratified by Pulse status and eGFR

You may not qualify if…

• Patients unfit for surgery
• Patients unable to provide informed consent
• Patients with overwhelming sepsis that require major amputation
• Patients with hypersensitivity to aminoglycosides
• Pre-existing calcium metabolism disorder
• Severe renal impairment
• Patients in whom major limb amputation is deemed inevitable by the treating physician

Where it is running

• University Hospital Galway — Galway, Ireland (enrolling)

Full record on ClinicalTrials.gov

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