Total Arterial vs. Mixed Grafting in Left Coronary CABG

Starting soon · Not applicable

Conditions studied: Coronary Artery Disease, Coronary Artery Bypass Grafting, Arterial Graft, Graft Patency, Major Adverse Cardiovascular Events

In brief

This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery and great saphenous vein) in the left coronary artery system during coronary artery bypass grafting (CABG). A total of 400 patients undergoing elective CABG at the Second Hospital of Jilin University will be enrolled and randomized into two groups. The primary endpoint is graft patency at 12 months postoperatively, evaluated by coronary angiography or CT angiography. Secondary outcomes include perioperative complications, major adverse cardiovascular events (MACE), and long-term clinical prognosis. The study aims to provide evidence-based guidance on optimal graft selection in CABG.

Key facts

Study ID

NCT07057713

Run by

Second Hospital of Jilin University

People needed

400

Starts

2026-08-01

Expected to finish

2027-12-30

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Diagnosed with multivessel coronary artery disease
• Indicated for elective coronary artery bypass grafting (CABG) involving ≥3 coronary vessels
• Right coronary artery stenosis >75%
• Able and willing to provide written informed consent

You may not qualify if…

• Scheduled for concurrent cardiac procedures (e.g., valve surgery, congenital heart disease repair, aortic dissection surgery, atrial fibrillation ablation)
• Severe stenosis of left or right subclavian artery
• Unsuitable saphenous veins (e.g., bilateral varicosities)
• Unsuitable radial artery as assessed preoperatively
• History of intracranial hemorrhage or ischemic stroke within the past 14 days
• Severe hepatic or renal insufficiency
• Acute myocardial infarction within 72 hours prior to surgery
• History of prior CABG or other cardiac surgery

Where it is running

• The Second Hospital of Jilin University — Changchun, Jilin, China

Full record on ClinicalTrials.gov

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