Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women
Enrolling by invitation · Phase 4
Conditions studied: Obesity, Menopause
In brief
In postmenopausal women, obesity increases the risk of physical function decline, premature aging, and vascular dysfunction. Semaglutide and tirzepatide are potent obesity medications. The goal is to determine the effect of weight loss induced by the new generation of GLP-1 receptor agonists on physical function, aging biomarkers, and vascular function in postmenopausal women with obesity.
Key facts
- Study ID
- NCT07057310
- Run by
- Mayo Clinic
- People needed
- 30
- Starts
- 2025-05-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-07-20
Who can join
Age: 46 and older, up to 60. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Postmenopausal women (with menopause defined as the cessation of menstrual periods for at least 12 months or history of bilateral oophorecomy)
- Age 46-60 years old
- BMI ≥ 30 kg/m2.
You may not qualify if…
- Past or current use of menopausal hormone therapy
- Early or premature menopause
- History of chemically induced menopause
- Impaired renal function (GFR ≤29)
- Thyroid-stimulating hormone ≥7 with low free T4
- Diabetes
- Cardiovascular disease
- Elevated blood pressure (>170/>95)
- Uncontrolled co-morbidities including inflammatory, autoimmune, infectious, hepatic, gastrointestinal, malignant, or psychiatric disease
- >5% change in weight during the 3 months prior to screening
- Other anti-obesity medication use within the past 3 months
- History of bariatric surgery
- History of malignant neoplasms within the past 5 years prior to screening
- Current use of supplements known to affect weight
- Personal or family history of medullary thyroid cancer.
- Wheelchair bound
- Vision loss
Where it is running
- Mayo Clinic in Florida — Jacksonville, Florida, United States
Full record on ClinicalTrials.gov
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