Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa

Recruiting now

Conditions studied: Osteomyelitis, Pseudomonas Infections, Pseudomonas Aeruginosa, Bacterial Infections

In brief

This study looks at how well one antibiotic (monotherapy) works compared to two antibiotics (combination therapy) in treating bone infections caused by Pseudomonas aeruginosa. It includes 300 adult patients who had this type of infection confirmed by lab tests and medical imaging. The goal is to find out if using just one antibiotic is as effective as using two, while also looking at side effects, the need for more surgery, antibiotic resistance, and overall antibiotic use.

Key facts

Study ID

NCT07056881

Run by

Centre Hospitalier de Saint-Denis

People needed

300

Starts

2025-04-11

Expected to finish

2026-04-15

Last updated by the study team

2025-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years old)
• Diagnosis of osteitis or osteomyelitis due to Pseudomonas aeruginosa
• Isolation of Pseudomonas aeruginosa from at least one deep, sterile sample (e.g., bone biopsy, joint aspiration)
• Imaging findings consistent with osteomyelitis (MRI, CT scan, or X-ray)

You may not qualify if…

• No isolation of Pseudomonas aeruginosa
• No imaging evidence suggestive of osteomyelitis
• Patients under 18 years of age

Where it is running

• Centre Hospitalier de Saint-Denis — Saint-Denis, France, France (enrolling)

Full record on ClinicalTrials.gov

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