UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Heart Failure, Polygenic Score
In brief
This study will use polygenic scores, a tool which describes differences in genetics, to examine effectiveness of beta blocker medication in heart failure patients with ejection fraction of 41-50 percent. The study will also assess beta blockers' effect on the changes in left ventricular end-systolic volume index by MRI.
Key facts
- Study ID
- NCT07054489
- Run by
- David Lanfear
- People needed
- 10
- Starts
- 2026-03-30
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-07-07
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-89 years
- Ejection Fraction (EF) >40% and =<50% by any modality within 1 year (must be most recent)
- Clinical diagnosis of HF within 1 year, evidenced by any one: Hospital discharge with primary or secondary HF diagnosis, ER discharge with primary diagnosis of HF, ambulatory diagnostic code for HF and diuretic use, BNP>35 ng/L or NTproBNP >125 ng/L at any time
- Expected ability to fully participate in study (can tolerate study processes, no long travel)
You may not qualify if…
- Unable to provide informed consent
- Previous documented EF =< 35%
- Currently on BB =>25% target dose
- Uncontrolled hypertension (systolic BP > 180 at enrollment)
- Has contraindications to all BB or intolerance to metoprolol
- Systolic BP < 100 or heart rate <70
- Current cancer requiring active treatment
- Heart transplant or LVAD or expected in the next year
- Life expectancy < 1 year for any reason
- Dialysis dependence or ESRD
- MI/ PCI or other cardiac surgery within 90 days prior to enrollment or planned in the future
- Absolute indication for BB other than heart failure (e.g. tachyarrhythmia required BB for rate control, angina)
- If PI decides for any reason participation in trial is not in best interest of the patient
- Has a contraindication to completing MRI procedures
Where it is running
- Henry Ford Health — Detroit, Michigan, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.