Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein
Recruiting now · Not applicable
Conditions studied: Indication for CSF Dynamic Testing, Indication for CSF Infusion Test
In brief
Elevated intracranial pressure (ICP) occurs when pressure inside the skull rises above normal levels, potentially leading to brain damage or herniation. Monitoring ICP is critical for managing conditions like brain tumors, traumatic brain injury, and stroke. Current ICP monitoring methods are invasive and carry risks, including infection and brain damage. For less severe cases, lumbar puncture is a safer, less invasive alternative. This study explores the potential of a non-invasive method, using venous pressure near the eye, to estimate ICP. The goal is to assess whether the results from this non-invasive approach are similar to the invasive lumbar CSF pressure measurements.
Key facts
- Study ID
- NCT07053631
- Run by
- University of Freiburg
- People needed
- 10
- Starts
- 2025-04-07
- Expected to finish
- 2025-12-08
- Last updated by the study team
- 2025-07-08
Who can join
Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Medical indication to perform routine craniospinal CSF dynamic testing according to standard operative procedures
- Aged 18-95
- Willing and able to provide valid signed informed consent
You may not qualify if…
- Patients with any known ongoing, or history of, abnormal CSF communication
- Patients with any kind of prior intervention for CSF diversion
- Patients with acute brain damage within the preceding 6 months
- Patients with transdural surgery within the preceding 6 months
- Head wounds or hematoma that could hinder access to measurement site
- Any known pathological condition linked to the orbital socket influencing venous outflow
Where it is running
- Klinik für Neurochirurgie, Universitätsklinikum Freiburg — Freiburg im Breisgau, Germany (enrolling)
Full record on ClinicalTrials.gov
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