Aggressive Disease Treatment Patterns and CtDNA HRR evaluatiON in High-volume metastatiC hORmone-sensitive Prostate Cancer in Russian FeDeration

Recruiting now

Conditions studied: Prostate Cancer

In brief

A multicentre observational study on treatment patterns and ctDNA HRR evaluation in aggressive high-volume metastatic hormone-sensitive prostate cancer in Russian Federation

Key facts

Study ID: NCT07052578
Run by: AstraZeneca
People needed: 400
Starts: 2025-06-30
Expected to finish: 2028-11-30
Last updated by the study team: 2026-07-10

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

Male patients aged ≥ 18 years old;
Signed ICF, including consent for blood samples ctDNA and ctDNA-based HRRm testing;
Metastatic hormone-sensitive prostate cancer (mHSPC) (de novo or progressed from earlier stages);
High-aggressive disease (Gleason 8-10);
High-volume disease (according to CHAARTED trial criteria: presence of 4 and more (≥4) bone metastases (including at least one (≥1) outside the vertebral column/pelvis) and/or 1 and more (≥1) visceral metastasis);
Availability of source medical documentation;
Known HRRm status based on tumour sample evaluation performed in routine practice.

You may not qualify if…

Participation in any interventional trial since the mPC diagnosis.
Progression to mCRPC.

Where it is running

Research Site — Arkhangelsk, Russia (enrolling)
Research Site — Barnaul, Russia (enrolling)
Research Site — Chelyabinsk, Russia (enrolling)
Research Site — Irkutsk, Russia (enrolling)
Research Site — Krasnodar, Russia (enrolling)
Research Site — Krasnoyarsk, Russia (enrolling)
Research Site — Moscow, Russia (enrolling)
Research Site — Nal'chik, Russia (enrolling)
Research Site — Nizhny Novgorod, Russia (enrolling)
Research Site — Obninsk, Russia (enrolling)
Research Site — Tomsk, Russia (enrolling)
Research Site — Tyumen, Russia (enrolling)
Research Site — Ufa, Russia (enrolling)
Research Site — Yekaterinburg, Russia (enrolling)
Research Site — Pskov, Russia
Research Site — Saint Petersburg, Russia
Research Site — Kazan', Russia
Research Site — Saint Petersburg, Russia
Research Site — Saransk, Russia
Research Site — Sochi, Russia
Research Site — Moscow, Russia
Research Site — Moscow, Russia
Research Site — Syktyvkar, Russia
Research Site — Tomsk, Russia
Research Site — Tver', Russia

Full record on ClinicalTrials.gov

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