The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
Recruiting now
Conditions studied: Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF), Obesity (Disorder)
In brief
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
Key facts
- Study ID
- NCT07052539
- Run by
- University of Mississippi Medical Center
- People needed
- 60
- Starts
- 2022-07-22
- Expected to finish
- 2026-07-31
- Last updated by the study team
- 2025-07-04
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults 18-75 years old
- Normal kidney function
- No heart failure
- BMI 25-30kg/m2
You may not qualify if…
- Diagnosis of chronic illness
- eGFR<60mL/min/1.73m2
- Pregnancy or breast feeding
- History of cutaneous or allergic reaction to iodine-based products of contrast dyes
- Hemoglobin levels <7mg/dL
- Acute illness or hospitalization event within 3 months
- Unable to stop NSAIDs
- Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
- Current use of nicotine or recreational drugs, chronic drinker
- Criteria for Cohort 2: Obese Participants without HFpEF
- Inclusion Criteria:
- Adults 18-75 years old
- eGFR >= 60 mL/min/1.73m2
- BMI > 35 kg/m2
- Exclusion Criteria:
- Diagnosis of Heart Failure
- Diagnosis of chronic illness
- eGFR<60mL/min/1.73m2
- Pregnancy or breast feeding
- History of cutaneous or allergic reaction to iodine-based products of contrast dyes
- Hemoglobin levels <7mg/dL
- Acute illness or hospitalization event within 3 months
- Unable to stop NSAIDs
- Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
- Current use of nicotine or recreational drugs, chronic drinker
Where it is running
- University of Mississippi Medical Center — Jackson, Mississippi, United States (enrolling)
Full record on ClinicalTrials.gov
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