The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM
Recruiting now
Conditions studied: Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured, Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral
In brief
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
Key facts
- Study ID
- NCT07050381
- Run by
- The First Affiliated Hospital with Nanjing Medical University
- People needed
- 200
- Starts
- 2025-06-13
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-07-03
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
- No history of stroke, Marfan syndrome, polycystic kidney disease
You may not qualify if…
- pAVM without flow-related aneurysms
- Absence of clinical data
Where it is running
- the First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (enrolling)
- Jiangsu Province Hospital — Nanjing, Jiangsu, China
Full record on ClinicalTrials.gov
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