Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation
Recruiting now · Phase 1
Conditions studied: Repetitive Head Impacts
In brief
The goal of this clinical trial is to test whether the gamma - glutamylcystiene (GGC) oral supplement can reach the brain and subsequently increase antioxidant glutathione (GSH) level in people with repetitive head impact (RHI). This will reduce the oxidative stress related injury in people with RHI.This unique study's main objective is to test the: 1. Change in GSH in brain and blood levels through GGC supplementation. 2. Change in the cognitive function in RHI patients due to GGC supplementation.
Key facts
- Study ID
- NCT07050173
- Run by
- Pravat Mandal
- People needed
- 30
- Starts
- 2026-05-01
- Expected to finish
- 2027-12-27
- Last updated by the study team
- 2026-06-03
Who can join
Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Retired NFL player, retired Navy SEAL/army personnel with combat experience exposed to repetitive head impact;
- Memory and behavioral complaint per self- or informant-report;
- Age (30 to 70 years of age) years;
- Able to read and write in English and to give consent to participate in the study.
You may not qualify if…
- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the eyes, skin, or body.
- Subjects with claustrophobia.
- Subject with mild cognitive impairment [TICS score of 29 or lower OR >=1.0 standard deviations below age-expectation on at least two cognitive members within the same cognitive domain (e.g. memory, attention, etc.) on the baseline neuropsychological testing;
- Subjects with a history of cancer;
- Subjects with active psychosis or delirium;
- Subjects with chronic kidney (creatinine > 1.5mg/dL) or liver disease (AST ≥ 1.5 ULN; ALT ≥1.5 ULN) within 30 days prior to enrollment;
- Subjects on antioxidant therapy (gingko biloba or N-acetylcysteine) or illicit drug abuse/dependence (cocaine, heroin, marijuana, or fentanyl;
- Repeated head injury patients with neurosurgical intervention and;
- Subjects with repeated head injury within the last 90 days.
Where it is running
- UPMC Presbyterian Hospital — Pittsburgh, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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