ICOPE INTENSE-K Pilot Study

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Ageing

In brief

ICOPE could constitute the reference model of care for healthy aging. More specifically, our hypothesis is that the intervention implemented in ICOPE may directly or indirectly prevent immuno-senescence, the loss of mobility and the cognitive decline. In future Geroscience clinical trials, ICOPE-Intense could become a benchmark to reduce the rate of aging with a strong non-pharmacological intervention and state a reference intervention to compare with new gerotherapeutic drugs.

Key facts

Study ID

NCT07048860

Run by

University Hospital, Toulouse

People needed

40

Starts

2025-07-09

Expected to finish

2025-12-31

Last updated by the study team

2025-07-23

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Independent-living (ADL ≥5/6)
• Men and women
• Mobility impairment (5 Chair-rise test >12 seconds)
• Sedentarism (spend six or more hours per day sitting or lying down)
• Positive screening for cognitive impairment according to the ICOPE screening tool with MMSE [25-28]
• BMI ≥25 kg/m2

You may not qualify if…

• Unintentional weight loss (≥10%) in past 6 months
• Dementia
• Life-threatening illnesses, with a life expectancy (judged by the investigating doctor) of less than 1 year
• Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina or any other contraindication to physical activity (as determined by a physician) or comorbid disease that would impair ability to participate in the ICOPE intense intervention such as renal failure on hemodialysis, severe psychiatric disorder (depressive participant will not be excluded)
• Organizational inability (three-time per week during the 60 days)
• Living in a Nursing-Home
• Under legal protection measure (guardianship, curatorship, safeguard of justice

Where it is running

• Cité de la santé - Hopital La Grave — Toulouse, France (enrolling)

Full record on ClinicalTrials.gov

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