Prehabilitation in Older People Undergoing Total Hip Replacement

Starting soon · Not applicable

Conditions studied: Hip Replacement in Osteoarthritis Patients, Osteoarthritis, Hip

In brief

The goal of this clinical trial is to determine the effect of Resistance Exercise Training (RET)-based (p)rehabilitation versus usual care on skeletal muscle mass and function, as well as on underlying biological processes, in older adults undergoing elective Total Hip Replacement (THR) due to severe Osteoarthritis (OA). The main questions it aims to answer are: * What is the effects of RET-based (p)rehabilitation versus usual care to improve muscle mass and function in patients undergoing elective unilateral THR surgery for end-stage OA? * What is the potential of certain circulating biomarkers to predict the efficacy of the musculoskeletal system response to RET in patients with severe OA? Researchers will compare RET-based (p)rehabilitation versus usual care to see if RET works to increase skeletal muscle mass and function. Participants in the usual care group will undergo standard rehabilitation (12 weeks post-surgery), and participants in the (p)rehabilitation group will undergo RET-based full-body (p)rehabilitation (3x/week) for 2 weeks pre-surgery and 12 weeks post-surgery.

Key facts

Study ID

NCT07048080

Run by

Universidad de La Frontera

People needed

70

Starts

2026-08-02

Expected to finish

2029-03-01

Last updated by the study team

2026-06-12

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals aged from 60 y and over.
• 18.5 < BMI < 40 kg/m2.
• Individuals on waiting list to undergo a unilateral elective surgery for Total Hip Replacement due to primary severe Osteoarthritis.

You may not qualify if…

• Individuals with severe OA in the contralateral hip.
• Individuals who has been performing regular RET (2 or more times per week) in the previous 6 months.
• Individuals who smoke.
• Significant psychiatric or neurological disorders, with the use of acetylcholinesterase inhibitors, and untreated mood disorders or depressive pathology.
• Neuromuscular or mobility disorders that prevent safe resistance training (debilitating arthritis, spasticity/rigidity, and paralysis), along with untreated metabolic disorders (such as uncontrolled systemic hypertension).

Where it is running

• Universidad de La Frontera — Temuco, Cautin, Chile

Full record on ClinicalTrials.gov

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