Ex Vivo Evaluation on Human Tissue of the Binding of Experimental Radiolabeled Ligands

Recruiting now

Conditions studied: Tissue Model

In brief

The HERO project aims to structure an ex vivo screening platform, based on anonymized human tissues, to early assess the tissue fixation of experimental ligands in an ethical, translational approach that complies with the principles of the 3Rs (Replacement, Reduction, Refinement).

Key facts

Study ID

NCT07047677

Run by

Central Hospital, Nancy, France

People needed

300

Starts

2025-11-01

Expected to finish

2030-09-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who underwent surgical resection at the Nancy University Hospital after 2019 (Information provided in the welcome booklet or on posters displayed in waiting rooms, mentioning the possible use of data or resection specimens, unless otherwise stated).
• No documented objection, in accordance with the MR004 methodology.
• Frozen human tissues (slides, blocks, or sections) from surgical resection or biopsy, transmitted by the CRB or the biopathology department.
• Samples are fully anonymized before being made available for analysis.

You may not qualify if…

• • Unusable tissue (degraded, insufficient, contaminated, poorly preserved).
• Lack of traceability of the material.
• Explicit opposition from the patient to the use of their tissue for research.

Where it is running

• Chru Nancy — Vandœuvre-lès-Nancy, France (enrolling)

Full record on ClinicalTrials.gov

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