Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Recruiting now · Not applicable

Conditions studied: Healthy Participants

In brief

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Key facts

Study ID

NCT07045051

Run by

Ball State University

People needed

24

Starts

2025-03-26

Expected to finish

2026-12-01

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 - 45 years.
• Body mass index between 18.5-35.0 kg/m2
• Not pregnant (females only)
• Not postmenopausal (females only).
• Not been diagnosed with cardiovascular disease.
• Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
• Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
• Does not regularly take anti-inflammatory drugs (more than 2x week).
• Does not use glucose-lowering drugs (e.g., metformin)
• Does not use lipid-lowering drugs (e.g., statins)
• Does not use tobacco products or any illicit drugs.
• Does not have a pacemaker.
• Can consume mango, wheat, gluten, and milk.
• Can stay in a supine position in the dark for at least ten minutes.

You may not qualify if…

• Not between the ages of 18-45
• Body mass index < 18.5 kg/m2 or >35.0 kg/m2
• Pregnant (females only)
• Postmenopausal status (females only).
• Been diagnosed with cardiovascular disease.
• Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
• Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
• Regularly take anti-inflammatory drugs (more than 2x week).
• Uses glucose-lowering drugs (e.g., metformin)
• Uses lipid-lowering drugs (e.g., statins)
• Uses tobacco products or any illicit drugs.
• Have a pacemaker.
• Allergic to mango, wheat, gluten, and/or milk.
• Unable to lay in supine position in the dark for at least ten minutes.

Where it is running

• Health Professions Building, Ball State University — Muncie, Indiana, United States (enrolling)

Full record on ClinicalTrials.gov

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