Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke

Recruiting now · Not applicable

Conditions studied: Ischemic Stroke, Obstructive Sleep Apnea

In brief

The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.

Key facts

Study ID

NCT07044830

Run by

Hospital das Clínicas de Ribeirão Preto

People needed

425

Starts

2024-02-28

Expected to finish

2031-02-28

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories
• Aged 18 to 80 years
• Symptom onset or symptom recognition to admission < 12 hours
• NIHSS score ≥ 4 and ≤ 20 at enrollment
• Signed informed consent form obtained from the participant or their legal representative

You may not qualify if…

• Prior stroke
• Previous diagnosis of OSA with current CPAP use or previously failed CPAP
• Pre-stroke disability (mRS > 1)
• Coma or stupor
• Orotracheal intubation
• Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure)
• Psychomotor agitation
• High likelihood of neurosurgical intervention within the first 48 hours
• Oxygen therapy >2 L/min
• Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions)
• Chronic alcohol or drug use with high risk of withdrawal during hospitalization
• Pregnant or suspected pregnant women
• Inability to complete follow-up for any reason
• Any contraindication to CPAP use

Where it is running

• Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo — Ribeirão Preto, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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