Social Functioning in Opioid Use Disorder
Recruiting now · Not applicable
Conditions studied: Opioid Use Disorder
In brief
Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood. This study will utilize both data from both patients with OUD and their concerned significant other (CSO) to examine associations between specific social functioning metrics and OUD treatment outcomes. Findings from this study will inform future precision-medicine approaches for people with OUD, a population in significant need of enhanced treatment approaches to combat opioid morbidity and mortality.
Key facts
- Study ID
- NCT07044466
- Run by
- Medical University of South Carolina
- People needed
- 230
- Starts
- 2026-08-31
- Expected to finish
- 2029-08-31
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Any sex or gender; any race or ethnicity; aged 18 years or older
- Patient participants must meet DSM-5 diagnostic criteria for current (i.e., past 12 months) OUD (assessed via the Quick Structured Clinical Interview for DSM-5; Quick SCID)
- Patient participants must be on buprenorphine, as prescribed by their provider, for no more than 4 weeks prior to study initiation
- Patient participants must be in treatment at one of the following clinics in the Charleston area: MUSC's Center for Drug and Alcohol Programs (CDAP) clinic, MUSC's Bridge Clinic, the Charleston Center, Hope Integrative Medicine, or BHG Charleston
- Concurrent substance use disorders (e.g., alcohol, cannabis) for the patient participant are acceptable, provided opioids are the patient participant's primary substance of choice
- Patient participants must identify a CSO participant who consents to participation in the study as well
You may not qualify if…
- Moderate-to-severe opioid withdrawal as defined by a score of ≥21 on the Subjective Opioid Withdrawal Scale
- Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders
- Current suicidal or homicidal ideation and intent; participants who present a serious suicide risk are likely to require hospitalization during the study and they will be referred clinically
- CSO participants meeting DSM-5 criteria for opioid use disorder or any other substance use disorder, excepting tobacco use disorder
- Severe interpersonal violence in the past six months between the patient and the CSO, as defined by an adapted version of the Conflict Tactics Scaled Revised (CTS-2)
- Pregnancy for patient participants
- Prisoners, institutional individuals, and children will not be recruited for this study.
Where it is running
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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