Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Recruiting now
Conditions studied: Peep Titration in Lung Protective Ventilation
In brief
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.
Key facts
- Study ID
- NCT07044089
- Run by
- Kocaeli University
- People needed
- 86
- Starts
- 2025-07-23
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2025-08-08
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
- Patients between the ages of 18 and 70
- ASA (American Society of Anesthesiologists) physical status classification II-III
You may not qualify if…
- Patients with an ejection fraction below 35%
- Patients who did not consent to participate in the study
- Patients undergoing emergency surgery
- Patients who are allergic to the anesthetic drugs used
- Patients who have undergone lung resection
- Those with a history of mechanical ventilation in the 2 months before surgery
- Patients who have undergone total circulatory arrest and deep hypothermia
- Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
- Morbid obesity (Body Mass Index>35kg/m2)
- Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
- COPD (FEV1<70%)
- Patients with chronic renal failure (serum creatine>1.8 mg/dl)
- Anemia (Hg<10 gr/dl)
- Patients who have had an intraaortic balloon pump placed.
Where it is running
- Kocaeli University Faculty of Medicine — Kocaeli, izmit, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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