A Clinical Trial Evaluating Injection of TQB6411 in Subjects With Advanced Malignant Tumors

Recruiting now · Phase 1

Conditions studied: Advanced Malignant Tumors

In brief

TQB6411 for injection is an antibody-conjugated drug (ADC) targeting EGFR/c-Met. After injecting blood intravenously, the antibody part of this product binds to the surface of EGFR and c-Met on tumor cells to block the activation of EGFR and c-Met signaling pathways. The ADC is enzymatically transported to the lysosome. The linker releases toxins after enzyme cleavage, resulting in DNA damage and cell death. TQB6411 for injection is intended for the treatment of advanced malignant tumors.

Key facts

Study ID

NCT07043751

Run by

Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.

People needed

216

Starts

2025-07-15

Expected to finish

2028-06-01

Last updated by the study team

2026-01-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The subjects voluntarily joined the study, signed an informed consent form, and had good compliance;
• 18 years old≤age age≤75 years old (calculated based on the date of signing the informed consent form);
• Eastern Cooperative Oncology Group (ECOG) score 0\~1 point;
• Expected survival is greater than 12 weeks;
• According to the RECIST v1.1 standard, there is at least one evaluable tumor lesion in the dose escalation stage, and at least one measurable lesion in the dose expansion stage;
• Laboratory examination standards that meet the program requirements (no use of hematopoietic stimulator drugs for correction within 7 days);
• Subjects who failed or were intolerant of standard treatment;
• Subject requirements for the dose expansion stage: advanced NSCLC; metastatic colon cancer; recurrent/metastatic esophageal squamous cell carcinoma; recurrent/metastatic nasopharyngeal carcinoma; advanced malignant solid tumor;
• Can provide tumor tissue specimens that meet the requirements for immunohistochemical testing;
• Women of childbearing age should agree that effective contraception must be adopted during the study period and within 6 months after the end of the study, and that the serum or urine pregnancy test will be negative within 7 days before the study enrollment; men should agree that effective contraception must be adopted within 6 months after the end of the study period;

You may not qualify if…

• Have appeared or are currently suffering from other malignant tumors;
• There are diseases that affect intravenous injection and intravenous blood collection;
• The adverse reactions of previous treatments failed to recover to CTCAE V5.0 grade score ≤1, except for toxicity without safety risk, such as grade 2 hair loss, grade 2 peripheral nerve toxicity, grade 2 anemia, non-clinical significance and asymptomatic grade 2 laboratory abnormalities, stable hypothyroidism with hormone replacement therapy;
• Those who have received major surgical treatment, obvious traumatic injury or major surgery during the expected study treatment within 4 weeks before the first medication (except for the surgery stipulated in the program), or have long-term uncured wounds or fractures;
• Subjects with any bleeding or bleeding events ≥CTC AE grade 3 within 4 weeks before the first dose;
• Arterial/venous thrombosis events occurred within 6 months before the first dose;
• People with active viral hepatitis and poor control;
• People infected with active syphilis who need treatment;
• There is a history of active tuberculosis, idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonia/radio-pneumonia that needs treatment, or active pneumonia with obvious clinical symptoms, and interstitial lung disease (ILD) that needs treatment, or currently associated with interstitial lung disease;
• Those with a history of abuse of psychotropic substances and cannot quit or have mental disorders;
• Preparing for or having previously received allogeneic bone marrow transplants or solid organ transplants;
• Have a history of hepatic brain disease;
• Suffering from major cardiovascular disease;
• Severe infection that is active or uncontrollable (≥CTC AE grade 2 infection);
• People who require hemodialysis or peritoneal dialysis if renal failure is required;
• Have a history of immunodeficiency, including HIV-positive or other acquired, congenital immunodeficiency diseases;
• Subjects who have poorly controlled autoimmune diseases and need to use immunosuppressive agents or systemic hormones to achieve immunosuppressive purposes and still need to continue using them within 7 days before the first dose (except for daily dose of glucocorticoid <10 mg prednisone or other therapeutic hormones);
• People with epilepsy and need treatment;
• Poor diabetes control [fasting blood sugar (FBG) > 10mmol/L];
• Tumor-related symptoms and treatment: subjects who have received chemotherapy, immunotherapy, small molecule targeted drugs, etc. within 3 weeks before the first dose, or are still in the 5 half-life of the drug; within 1 week before the first dose, they have received Chinese patent medicine treatment with anti-tumor indications in the National Medical Products Administration (NMPA) approved drug instructions; imaging (CT or MRI) shows that the tumor has invaded important blood vessels or the researchers judged that the tumor is very likely to invade important blood vessels during the subsequent study and causing fatal major bleeding; if it is not controlled, pleural effusion, pericardial effusion or moderate and severe ascites that still require repeated drainage; known to suffer from spinal cord compression, meningeal metastasis/cancer meningitis, accompanied by brain metastasis symptoms or symptoms/image control time is less than 4 weeks;
• Known allergies to research drugs or excipients;
• Have received previous treatment for Epidermal Growth Factor Receptor (EGFR)/c-Mesenchymal-epithelial transition dual anti-ADC drugs;
• Those who participated in and used other anti-tumor clinical trial drugs within 4 weeks before the first medication;
• According to the researcher's judgment, there are situations that seriously endanger the safety of the subject or affect the subject's completion of the study.

Where it is running

• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (enrolling)
• Jining First People's Hospital — Jining, Shandong, China
• Shanghai Jiaotong University School of Medicine, Renji Hospital — Shanghai, Shanghai Municipality, China
• Shanghai Pulmonary Hospital — Shanghai, Shanghai Municipality, China
• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
• Sichuan Cancer Hospital — Chengdu, Sichuan, China
• West China Hospital, Sichuan University — Chengdu, Sichuan, China
• Mianyang Central Hospital — Mianyang, Sichuan, China
• Tianjin Medical University Cancer Institute & Hospital — Tianjin, Tianjin Municipality, China
• Beijing Friendship Hospital, Capital Medical University — Beijing, Beijing Municipality, China
• Dongguan People's Hospital — Dongguan, Guangdong, China
• ZhuJiang Hospital of Southern Medical University — Guangdong, Guangdong, China
• Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
• Anyang Tumor Hospital — Anyang, Henan, China
• The Henan Cancer Hospital — Zhengzhou, Henan, China
• Zhongnan Hospital Of Wuhan University — Wuhan, Hubei, China
• the Second Xiangya Hospital of Central South University — Changsha, Hunan, China
• The First Hospital of China Medical University — Shenyang, Liaoning, China
• Jiangsu Province Hospital — Nanjing, Jiangsu, China

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.