Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Anterior Cruciate Ligament Reconstruction

Recruiting now · Not applicable · Has a placebo group

Conditions studied: ACL - Anterior Cruciate Ligament Rupture

In brief

With the intention of improving rehabilitation after anterior cruciate ligament reconstruction, the present project investigates the influence of a targeted strength and blood flow restriction training intervention (BFR training) on the regeneration of muscle mass, strength and functionality of the knee joint. BFR training is characterized by the combination of external venous vascular occlusion with light strength training and still enables users to achieve gains in muscle mass and strength that are comparable to training with high mechanical loads. The positive effects of BFR training in the course of knee arthroplasty have already been demonstrated by our working group as a prehabilitative approach, i.e. as a training intervention prior to surgery. In the present project, the framework conditions of outpatient rehabilitation at the Bonn Center for Outpatient Rehabilitation will now be used to prove whether sports science-controlled strength and BFR training has a similar effect in the postoperative rehabilitation phase. The interventions are carried out as part of the exercise therapy units in outpatient rehabilitation ETM01 in accordance with the S2k guideline on anterior cruciate ligament rupture. Strength and BFR training in medical training therapy supplements the daily exercise therapy to ensure implementation in the rehabilitation process in line with the guidelines.

Key facts

Study ID

NCT07043569

Run by

University Hospital, Bonn

People needed

30

Starts

2025-06-20

Expected to finish

2026-12-31

Last updated by the study team

2025-12-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ACL reconstruction
• Ability to take part in an outpatient rehabilitation

You may not qualify if…

• Sickle Cell anemia
• iatrogenic changes in the vessels of the lower limbs (stents, bypasses)
• inflammation of the lower extremities

Where it is running

• University Hospital Bonn — Bonn, North Rhine-Westphalia, Germany (enrolling)

Full record on ClinicalTrials.gov

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