Measuring Acute Drug Demand in Humans II
Withdrawn before enrolling · Early Phase 1 · Has a placebo group
Conditions studied: Healthy Volunteers
In brief
This research is being done to evaluate the impact of various drugs and combinations of drugs on mood, pain, and performance.
Key facts
- Study ID
- NCT07043452
- Run by
- Johns Hopkins University
- People needed
- 0
- Starts
- 2025-11-15
- Expected to finish
- 2027-12-30
- Last updated by the study team
- 2025-11-12
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged 18-55 years
- Vital signs in normal range as reviewed by study medical team
- Person is willing and able to provide informed consent
You may not qualify if…
- Evidence of physical dependence on alcohol or benzodiazepines based on tolerance and withdrawal upon cessation of use of alcohol or benzodiazepines reported in the Mini-International Neuropsychiatric Interview (MINI) as well as clinical interviews by medical staff during H\&P.
- Seeking treatment for alcohol or substance use
- Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
- Active hepatic disease or abnormal liver function tests
- Current major depressive disorder or suicidality
- Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding. People of childbearing potential will be asked to ensure, and/or the partner use effective forms of contraception for the duration of the study and excluded if unable.
- Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.
- Contraindications or allergies to study medications
- Evidence of recent illicit substance use (i.e., positive urinalysis) at screening for drugs other than cannabis
- Seizure disorder or traumatic brain injury (TBI)
- Taking medications known to interact with study medications
Where it is running
- Behavioral Pharmacology Research Unit, Baltimore — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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