Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Starting soon
Conditions studied: Kidney Calculi, Ureteral Calculi
In brief
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1. Comparing the gut microbiota composition between kidney stone patients and healthy controls, with emphasis on analyzing the relative abundance of Lactobacillus salivarius 2. Comparing the differences in tryptophan metabolite levels such as indole-3-carboxylic acid (ICA) and kynurenine (Kyn) in serum between the two groups 3. Exploring the correlation between gut microbiota composition and tryptophan metabolite levels 4. Analyzing the influence of different environmental conditions (seasons, temperature and humidity) on gut microbiota and metabolite levels
Key facts
- Study ID
- NCT07043374
- Run by
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- People needed
- 270
- Starts
- 2026-09-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-01-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion criteria for patients with kidney stones
- Age>=18 years;
- Diagnosed with kidney stones by ultrasound, CT or urography;
- Willing to provide stool samples and serum samples for study;
- No history of antimicrobial use in the past 3 months;
- Signed and dated informed consent indicating that the patient or his/her legal representative is fully informed of the study-related information and agrees to participate.
- Inclusion criteria for the healthy control group
- Age>=18 years;
- No history of kidney stones and family history;
- Imaging examination (such as abdominal ultrasound) showed no kidney stones;
- Willing to provide stool samples and serum samples for research;
- No history of antibiotic use in the past 3 months;
- Signed and dated informed consent indicating that the volunteer is fully informed about the study-related information and agrees to participate.
You may not qualify if…
- Use of antimicrobials or probiotics within the past 3 months;
- Presence of active urinary tract infection;
- Presence of other serious systemic diseases, such as hepatic or renal insufficiency, cardiac or pulmonary diseases, malignant tumors, and immunodeficiency states;
- Congenital urinary tract abnormalities;
- Previous history of kidney transplantation or urinary diversion surgery;
- Pregnant or lactating women;
- Presence of chronic intestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, etc.;
- Inability to provide samples or complete follow-up according to the research protocol;
- Participation in other clinical studies within the past 3 months;
- Other conditions deemed unsuitable for participation in this study by the researcher.
Full record on ClinicalTrials.gov
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