Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients

Recruiting now

Conditions studied: Acute Myocardial Infarction (AMI)

In brief

The goal of this prospective cohort study is to investigate the relationship between the TyG index and early identification of MVO in AMI patients undergoing emergency PCI and CMR imaging. The study will enroll approximately 300 AMI patients treated at Xiangya Third Hospital of Central South University from June 2024 to August 2025. The main questions it aims to answer are: * How does the TyG index correlate with the early detection of MVO? * What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.

Key facts

Study ID

NCT07042321

Run by

The Third Xiangya Hospital of Central South University

People needed

300

Starts

2024-06-01

Expected to finish

2025-08-31

Last updated by the study team

2025-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years.
• STEMI symptom onset time < 12 hours.
• STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias.
• Very high-risk NSTEMI; undergoing emergency PCI treatment.
• Voluntary signed informed consent form.

You may not qualify if…

• Non-obstructive acute myocardial infarction.
• Severe chronic kidney disease (defined as estimated glomerular filtration rate <20 mL/min per 1.73 m²).
• Pregnant women or those planning to become pregnant.
• Failure of emergency PCI.
• Unclear CMR images

Where it is running

• Xiangya Third Hospital of Central South University — Changsha, Hunan Province,China, China (enrolling)

Full record on ClinicalTrials.gov

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