Natural History of Advanced Chronic Liver Diseases

Recruiting now

Conditions studied: Cirrhosis, Advanced Chronic Liver Disease

In brief

This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.

Key facts

Study ID

NCT07042308

Run by

Chinese University of Hong Kong

People needed

500

Starts

2024-09-25

Expected to finish

2035-12-01

Last updated by the study team

2025-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 or above
• Known ACLD, defined by:
• LSM > 10kPa or
• Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy.

You may not qualify if…

• Current or past history of hepatocellular carcinoma (HCC)
• History of liver transplantation
• Asplenism or history of splenectomy
• Serious medical illness with limited life expectancy of less than 6 months
• Pregnancy
• Unable to obtain or refusal of informed consent from patient

Where it is running

• Prince of Wales Hospital — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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