24-h Energy Expenditure and Anti-obesity Medication

Enrolling by invitation

Conditions studied: Obesity

In brief

This study investigates the long-term effects of anti-obesity medications (Semaglutide and Tirzepatide) on energy metabolism (24-hour energy expenditure and substrate oxidation) and body composition via Dual-energy X-ray absorptiometry (DXA)

Key facts

Study ID

NCT07041983

Run by

University of Pisa

People needed

30

Starts

2025-07-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body mass index (BMI) >= 30 kg/m² or >= 27 kg/m² with at least one weight-related comorbidity and stable body weight (±2 kg in prior 3 months)
• informed consent, adherence to study protocol, negative pregnancy test and contraception use (if applicable), and absence of cardiovascular events or end-organ damage.

You may not qualify if…

• psychiatric conditions impairing adherence, history of medullary thyroid cancer, pregnancy/lactation
• diabetes

Where it is running

• university hospital of Pisa — Pisa, Italy

Full record on ClinicalTrials.gov

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