MINT Conditioning to Improve Gait
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Stroke, Stroke Gait Rehabilitation
In brief
This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function.
Key facts
- Study ID
- NCT07041775
- Run by
- Northwestern University
- People needed
- 72
- Starts
- 2026-06-04
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2026-06-08
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age at enrollment is 18 to 85
- Leg impairment from unilateral stroke at least 6 months prior to screening
- Severe to moderate gait impairment (ambulatory with a maximum walking speed of 0.8 m/s, i.e., half of normal speed)
- Able to stand without assistance
- Clinically observable gait asymmetry
- Abnormal co-activation between adductor magnus and rectus femoris (R greater than or equal to 0.5)
You may not qualify if…
- Cognitive impairment with at least moderately impaired attention on digit-span test, or unable to follow instructions of the MINT task
- Visual impairment (such as hemianopia) preventing sufficient perception of the screen to play the games
- Anesthesia or severe neglect in the affected leg, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) that impairs ability to play the games
- Participation in another study on the affected leg, or any pharmacological study, within 6 weeks of enrollment
- Inability to understand or follow commands in English due to aphasia or other reason that makes it impossible to perform the training
- Diffuse or multifocal infarcts
- Substantial leg or other pain preventing participation for 60 minutes a day
- Spasticity treatment (pharmacological or Botox) on the affected leg within past 3 months
- Severe osteoporosis causing hip or other fractures
- History of multiple falls within the last year, use of walker for balance, or falling during stance while in the lab in the first session.
- Contracture limiting the range of motion of the leg
- Current pregnancy
- From the TMS portion of the study only: History of epilepsy in adulthood requiring antiseizure medications; recent/current alcoholism or benzodiazepine/barbiturate abuse or recent history of alcohol/benzodiazepine/barbiturate withdrawal, recent history of cocaine or amphetamine use, skull fractures or skull deficits, concussion within the last 6 months, unexplained recurring headaches, vagus nerve stimulator, cochlear implant, deep brain stimulator, intracranial/carotid stents, cardiac pacemaker/AICD.
Where it is running
- Northwestern University — Chicago, Illinois, United States (enrolling)
- University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.