A Trial of Varenicline for E-cigarette Cessation

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: E-cigarette Use, Vaping, Nicotine Dependence

In brief

This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.

Key facts

Study ID

NCT07040566

Run by

Yale University

People needed

326

Starts

2025-10-14

Expected to finish

2030-10-30

Last updated by the study team

2025-12-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• report daily use of an e-cigarette containing nicotine
• live in Connecticut or South Carolina

You may not qualify if…

• regular use of other tobacco products besides e-cigarettes
• medical contraindications for varenicline use
• current treatment for tobacco cessation
• lack proficiency in English

Where it is running

• Yale Cancer Center/Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut, United States (enrolling)
• Hollings Cancer Center at MUSC (HCC) — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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