Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Running, not enrolling · Early Phase 1

Conditions studied: Sedation, Interventional Radiology, Biopsy, Drainage Procedure

In brief

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Key facts

Study ID

NCT07040163

Run by

CAMC Health System

People needed

276

Starts

2025-03-07

Expected to finish

2026-06-01

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Planned to undergo image-guided bone biopsy, lung biopsy, or percutaneous drainage
• Eligible to receive ketamine or fentanyl sedation
• Any sex/gender, any race
• Aged 18-89

You may not qualify if…

• Pregnant/lactating
• Incarceration
• Currently taking an opioid agonist/antagonist
• Food consumed in past 6-8 hours
• Allergies to drugs used in the study
• Lacks mental capacity for reporting pain scores
• Hypotension or respiratory failure precluding fentanyl sedation
• Uncontrolled hypertension precluding ketamine sedation
• Condition for which hypertension would be a concern
• Schizophrenia

Where it is running

• CAMC Memorial — Charleston, West Virginia, United States

Full record on ClinicalTrials.gov

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